Blar i forfatter "Norwitz, Errol R."

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    • Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence 

      Lekva, Tove; Roland, M.C.P.; Estensen, M.E.; Norwitz, Errol R.; Tilburgs, T.; Henriksen, Tore; Bollerslev, Jens; Normann, K.R.; Magnus, P.; Olstad, Ole Kristoffer; Aukrust, Pål; Ueland, T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-05)
      Senescence in placenta/fetal membranes is a normal phenomenon linked to term parturition. However, excessive senescence which may be induced by telomere attrition, has been associated with preeclampsia (PE). We hypothesized that the telomerase complex in peripheral blood mononuclear cells (PBMC) and circulating telomere associated senescence markers would be dysregulated in women with PE. We measured ...

    • Platelet and mitochondrial RNA is decreased in plasma-derived extracellular vesicles in women with preeclampsia—an exploratory study 

      Lekva, Tove; Sundaram, Arvind; Roland, Marie Cecilie; Åsheim, June; Michelsen, Annika Elisabet; Norwitz, Errol R.; Aukrust, Pål; Gilfillan, Gregor; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-23)
      Background - Circulating extracellular vesicles (EVs) are increased in preeclampsia (PE) and are associated with severity and progression. We examined in this exploratory cohort study if the mRNAs and long noncoding RNAs (lncRNAs) in plasma-derived EVs were dysregulated in PE compared to normal pregnancy and display different temporal patterns during gestation.<p> <p>Methods - We isolated EVs ...

    • Prediction of gestational diabetes mellitus and pre-diabetes 5 years postpartum using 75 g oral glucose tolerance test at 14-16 Weeks' gestation 

      Lekva, Tove; Godang, Kristin; Michelsen, Annika E.; Qvigstad, Elisabeth; Normann, Kjersti R.; Norwitz, Errol R.; Tore, Henriksen; Bollerslev, Jens; Roland, Marie; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-06)
      Early detection and treatment of women at risk for gestational diabetes mellitus (GDM) could improve perinatal and long-term outcomes in GDM women and their offspring. We explored if a 75 g oral glucose tolerance test (OGTT) at 14-16 weeks of gestation could identify women who will (1) develop GDM or give birth to large-for-gestational-age (LGA) babies in 1031 pregnant women from the STORK study ...